The best answer i see is C) The natural features in an area include mountains, deserts, and oceans because these were all aspects of keeping native people from wondering to far.
Tobacco
It was the most profitable cash crop and most farms were harvesting it to sell back to Europe.
B. Hygiene and sanitation were very poor at the time of the outbreak. This is because germs were not considered harmful so sanitation and hygiene were unimportant.