Shay's rebellion was mostly lead by farmers who were upset by their taxes and debts and decided to take matters into their own hands. They did not want their property taken from them, as this happened when they were not able to pay their debts and/or taxes, so they forced closure of multiple courts throughout Massachusetts. Blood was shed, and eventually Shay's rebellion caused the Constitutional Convention of 1787 which discussed changing the Articles of Confederation which maintained the weak government system and caused many problems. After this the Constitution was created.
Jefferson's Kentucky Resolution (drafted in 1798) introduces the theory of nullification. This means that states, individually, can judge a central government law and declare it unconstitutional if they desire to do so.