Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
They help to prevent the disease from occurring. The immune system becomes familiar with the pathogen and learns how to fight it. Its the same process with vaccines
Answer:
What it means to be proffesional is to go to work and don't bring ypur personal problems to work, and don't come to work hungover/drunk, etc. When you're a proffesional person, while your assisting patients you shouldn't argue with other doctors or nurses.
If you wanna look professional you should come to work dressed in the scrubs they provide you with. You shouldn't come to work with crop tops and super short shorts on. When you do go to work you shouldn't have a bad body odor.
explanation:
Srry if im wrong :)
Answer: 0.33ml
Explanation:
What you have: 1,200,000 units/2ml
What you need: 400,000 units/x
1,200,000/2ml x 400,000/x =
400000/1,200,000 = 0.33ml
check answer: 0.33333333 x 1,200,000= 400,000 units
Answer:
Explanation:
he sports physical therapist (SPT) is uniquely qualified to participate in the provision of preparticipation physical examinations (PPE). The PPE is recommended prior to athletic participation and required by many jurisdictions. There is little research to support the process and components; however, a number of professional organizations have recommendations that direct the PPE process.
