People commit crimes for many different reasons. whether it is for the excitment and thrill of it or whether they were forced to or peer preasured on by another person. Maybe they robbed a bank cause they needed money or they were under the influence of drugs or alchohol
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One of the common genetic disorders is sickle cell anemia, in which 2 recessive alleles must meet to allow for destruction and alteration in the morphology of red blood cells. This usually leads to loss of proper binding of oxygen to hemoglobin and curved, sickle-shaped erythrocytes. The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit β (β-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 α chains and 2 β chains that is responsible for binding to the oxygen in the blood. This mutation changes a charged glutamic acid to a hydrophobic valine residue and disrupts the tertiary structure and stability of the hemoglobin molecule. Since in the field of protein intrinsic disorder, charged and polar residues are typically considered as disorder promoting, in opposite to the order-promoting non-polar hydrophobic residues, in this study we attempted to answer a question if intrinsic disorder might have a role in the pathogenesis of sickle cell anemia. To this end, several disorder predictors were utilized to evaluate the presence of intrinsically disordered regions in all subunits of human hemoglobin: α, β, δ, ε, ζ, γ1, and γ2. Then, structural analysis was completed by using the SWISS-MODEL Repository to visualize the outputs of the disorder predictors. Finally, Uniprot STRING and D2P2 were used to determine biochemical interactome and protein partners for each hemoglobin subunit along with analyzing their posttranslational modifications. All these properties were used to determine any differences between the 6 different types of subunits of hemoglobin and to correlate the mutation leading to sickle cell anemia with intrinsic disorder propensity.
Explanation:
Answer: False
Explanation: Pitch does not depend on how fast or slow an object vibrates.
Answer:
In systems, the relationships between individual parts may be more important than the parts. An ecosystem is not just a collection of species, but includes living things interacting with each other and their nonliving environment. In the systems view, the "objects" of study are networks of relationships.
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Answer:
missense
Explanation:
missense: alteration of one or more codons so that different amino acids are determined
silent mutation: mutations in DNA that do not have an observable effect on the organism's phenotype
