Answer:
Competitive inhibitors compete with the substrate to enter the active site of the enzymes thanks to their chemical affinity with them, thus blocking the enzyme's action with the original substrate.
Non-competitive inhibitors do not interact directly with the active site of the enzymes, but adhere to them by other sites, changing their structure and thus decreasing their affinity for the original substrate, blocking their functioning.
Competitive inhibition can be overcome by increasing the substrate concentration because the probability that the enzyme interacts with the inhibitor molecules will be lower, and the expected reaction will take place.
Explanation:
Non-competitive inhibition cannot be overcome by increasing the concentration of the substrate because the inhibitor, by interacting with the enzyme and changing its structural configuration, will prevent the enzyme from succeeding in inserting the substrate into its active site, also preventing the chemical reaction.
