Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
left ventricle
Explanation:
left ventricle pumps oxygen rich blood to the body (away from the heart, so through the arteries)
<h3>
♫ :::::::::::::::::::::::::::::: // Hello There ! // :::::::::::::::::::::::::::::: ♫</h3>
➷ The correct answers would be:
phosphate molecule, nitrogenous base and deoxyribose sugar.
<h3><u>
❄️</u></h3>
➶ Hope This Helps You!
➶ Good Luck (:
➶ Have A Great Day ^-^
↬ ʜᴀɴɴᴀʜ ♡
The lymph is moved through the body in its own vessels making a one-way journey from the interstitial spaces to the subclavian veins at the base of the neck. Since the lymphatic system does not have a heart to pump it, its upward movement depends on the motions of the muscle and joint pumps.
