Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Answer:
What is a. A; A
Explanation:
Drop 1 struck the surface from direction A, and drop 2 struck the surface from direction A.
Answer:
B.) an earthquake
Explanation:
earthquake, volcanoes, tsunamis and landslides are naturally occurring events that can rapidly change earth's surface
The rigth answer is the picture 4.
In the case of a hypotonic extracellular medium, there will be a large inflow of water to dilute the Na, thereby increasing the cell volume and there will be an explosion of the membrane in places so hemolysis, the contents of the red cell ( Hemoglobin) is released into the blood plasma.
On the other hand, in the case where the extracellular medium is hypertonic, therefore archi concentrated, well it will be the water of the red cell that will come out without damaging the membrane, we will rather have a red cell that is completely flat and non-functional without release. erythrocyte (Hb) content.
Answer:
Its Euglena
Explanation:
Shape change from normal elongated egg-shape to round-shape in stressful environment. These shape changes attain two transition phases. The I-transition phase is reversible where the organism can return to normal if favourable environment persists.
