<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
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by looking at their physical features, the fossil record, and dna sequences
<span>Charles Darwin theory is theory of biological </span>evolution, that explains how modern organisms evolved over long periods of time through descent from common ancestors. Evolution is the process of change over time and Darwin explains in his theory the changes in humans over time and <span>shows how the living world is constantly changing.</span> This is the reason why cientists refer to charles darwin’s ideas about evolution as the theory of evolution.
Explanation:
Iodophor -
Iodophor is a complex of iodine , with solubilizing agents , such as the povidone , surfactant .
And forms a water - soluble material which can release free iodine in the solution phase .
Dilute form of iodophor is used by winemakers and brewers to sanitize their equipment and bottles .
The major advantage of iodophor over other is that , it increases the stability of iodine .
Answer:
4? am aint sure sorry,but base on the website 4
