OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Answer:
xXMonkey explains your answer!
Explanation:
The reason the passenger pigeon went extinct is because of the mass hunting that went on. The reason they were hunted was for their meat, which exploded in the market. Soon, their numbers started dwindling, and they were quickly approaching their demise.
Before long, the passenger pigeon was gone. The extinction of this species sent a ripple through the world. In a simple explanation, no more pigeons, no more pigeon meat. This was kind of the first step to conservation. The passenger pigeon, in a way, gave itself up for conservation and the protection of the other species. Thank you for reading.
Hope this helps. -xXMonkey
The correct answer is <span>A. He does not approve of them.
That is because Mr. Gradgrind believed that it was not a respectable job and that people who value themselves should not be doing it.</span>
