Answer:
First choice, mutation!
Explanation:
Sickle cell anemia is caused by a mutation in the gene that tells your body to make the iron-rich compound that makes blood red and enables red blood cells to carry oxygen from your lungs throughout your body (hemoglobin).
Well, morphine is an opiod, and mainly attaches to the mu receptors if I recall correctly. that makes it insanely addictive if not prescribed correctly. it also shares an almost identical chemistry to heroine. it's actually just a less concentrated form of it.
muscles are contractile tissue and burn the unwanted calories than fat does
hope you are satisfied with my answer