the nervous system and endocrine system (hormones) is that the nervous system uses electrical impulses to send messages through neurons while endocrine glands use hormones to send messages to the target cells through the bloodstream.
Hormones can be proteins, lipids or cholesterol-based molecules. Neurotransmitters are protein. The main difference between hormones and neurotransmitters is that Hormones are produced in the endocrine glands and released into the bloodstream where they find their movement targets at a distance from their origin. In contrast, Neurotransmitters are released into the synaptic space by a terminal of an excited presynaptic nerve cell and transmit a nerve signal to the neighboring postsynaptic nerve cell.
