Which of the following is not true of the N terminal tail of these histones? The core histones are small, basic proteins that ha
ve a globular domain at the C-terminus and a long extended conformation at the N-terminus. A. It is subject to a covalent modifications
B. It extends out of the nucleosome core
C. It binds to DNA in a sequence-specific manner
D. It helps DNA pack tightly
E. It contains lysine residues
The correct answer is option C. "It binds to DNA in a sequence-specific manner".
Explanation:
It is not true that histones bind to DNA in a sequence-specific manner. Histones and DNA have nonspecific bindings (occuring at any DNA sequence) given mostly by electrostatic interactions. DNA is a macromolecule that is highly negatively charged because of its phosphate residues, while histones are proteins that are highly positively charged because of its high content of positively charged amino acids. In consequence, the binding of histones and DNA occurs mostly in a nonspecific fashion given by electrostatic interactions.
Protein synthesis is the process whereby DNA encodes for the production of amino acids and proteins. This process can be divided into two parts: Transcription and Translation.
In complete dominance, only one allele in the genotype is seen in the phenotype. In codominance, both alleles in the genotype are seen in the phenotype. In incomplete dominance, a mixture of the alleles in the genotype is seen in the phenotype.
