Question

Which of the following modifications are most likely to result in the formation of euchromatin?

Answer 1

A

Euchromatic is the less densely packed regions of DNA that are accessible to transcription proteins and enzymes like RNA polymerase. Euchromatic have fewer nucleosomes (as a result of fewer histone complexes), unlike heterochromatic regions.

Explanation:

Acetylation of lysine residues in histones removes the positive charges of the residues that allow the histones tails to interact with the negatively-charged phosphates of DNA. This reduced interaction means fewer nucleosomes in the DNA region hence a more relaxed state (euchromatin) of DNA.

DNA methylation, on the other, is the addition of a methyl group to CpG regions of DNA. This makes the DNA more interactive with histone tails. The regions, therefore, become tightly packed into nucleosomes hence making it condensed and inaccessible to proteins and enzymes like RNA polymerase.

Learn More:

For more on DNA methylation and histone modification check out;

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