Individuals with glucose-6-phosphate dehydrogenase deficiency have increased resistance to malaria because the parasite does not survive well in cells with oxidative stress.

<h3>What is the link between G6P deficiency and malaria?</h3>

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disorder.
G6PD protects cells from oxidative damage especially the RBCs whose main function is to carry oxygen.
Mutation in the gene results in G6PD deficiency leading to oxidative stress which can lead to anemia (iron deficiency) as there is breakdown of RBCs.
However, G6PD deficiency is quite common in parts of Africa, Middle East, and South Asia, which are the regions of high malaria endemism.
This is due to natural selection in which G6PD deficiency is not eliminated from the population as it can protect people from malaria infection.
Malaria parasite <em>Plasmodium</em> species does not survive well in cells with oxidative stress.

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nirvana33 [79]

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