Question

Suppose a geneticist mutates the gene for the poly(A) tail‑binding protein (PABP) in an eukaryotic cell line. The resulting mutant protein cannot bind to poly(A) tails. What is the effect of the PABP mutation in the cultured cells? Translation will not occur in the cultured cells, because mRNAs will be degraded at a greater rate than normal. Translation will occur in the cultured cells, but the resulting polypeptide will be longer than normal. Transcription will not occur in the cultured cells, because PABP is an essential transcription factor. Transcription will occur in the cultured cells, but the resulting transcript will be longer than normal. Replication will not occur in the cultured cells, because PABP determines the location of the origin of replication.

Answer 1

Answer:

Translation will not occur in the cultured cells, because mRNAs will be degraded at a greater rate than normal.

Explanation:

The poly(A) tail-binding protein (PABP) is known to be fundamental to the RNA processing and consequently in cellular function. Mutations in this protein will have negative effects on the initiation of translation