Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
Calculating Currents: Current in a Truck Battery and a Handheld Calculator ... (b) How long does it take 1.00 C of charge to flow through a handheld calculator if a 0.300-mA current is ...
Before cellphones are able to be used to browse the internet, play games, record videos and take photos, its main purpose is similar to a telephone, albeit it is more portable. Early cellphones would not have games for you to play, not would it have emails for you to check, read, and reply to. Though ringtones might seem as an acceptable option, early cellphones would also have many selections or even any for you to choose.
Thus, the best option would be (B) contact list, which is necessary for a cellphone to have since the owner would need the number to be able to make a call.
You would use a database to hold information in the servers.
Answer:
There are two basic operational modes of 8255:
Bit Set/Reset mode (BSR mode).
Input/Output mode (I/O mode).
Features of 8255 Microprocessor:
Mode 0 : Simple Input/Output.
Mode 1 : Input/Output with handshake.
Mode 2 : Bi-directional I/O data transfer.
It has three 8-bit ports : Port A, Port B, and Port C, which are arranged in two groups of 12 pins.
The 8255 can operate in 3 I/O modes : (i) Mode 0, (ii) Mode 1, & (iii) Mode 2.
