This is because the seven-sugar intermediate is synthesized by sugar addition to cytosolic-facing dolichol phosphate. The intermediate is flipped from the cytosol face of the ER membrane to the the luminal face. Additionally, the sugar additions then occur within the lumen of the ER. The short forms of the intermediate are on the wrong side of the membrane to add to nascent polypeptides within the ER lumen. Incomplete adductants within the ER lumen are located appropriately to N-glycosylate nascent polypeptide.
People with two copies of the sickle cell gene have the disease. People who carry only one copy of the sickle cell gene do not have the disease, but may pass the gene on to their children. Abnormal hemoglobin, called hemoglobin S, causes sickle cell disease (SCD). The problem in hemoglobin S is caused by a small defect in the gene that directs the production of the beta globin part of hemoglobin. This small defect in the beta globin gene causes a problem in the beta globin part of hemoglobin, changing the way that hemoglobin works.
Answer:
75%
Explanation:
not sure plz tell me if i`m right wrong
Answer:
translation
Explanation:
Translation takes place at a ribosome in the cytoplasm. During translation, the genetic code in mRNA is read to make a protein.
