A strain of Chlamydia trachomatis appears to have acquired a mutation in the 30S (small) ribosomal subunit, preventing drug bind
ing. Other than the mutation in the small ribosomal subunit, its ribosome structure appears otherwise unchanged. Based on this mutation, which of the following drugs would you expect to see decreased efficacy with this mutant strain?A. Erythromycin B. Tetracycline
C. Clindamycin
D. Chloramphenicol
According to the information sought, the option of tetracyclines would be, since the treatments with chlamydias are treated with this type of drug, if said bacterium alters the 30S subunit then the union with these drugs will be affected and therefore they will have less efficacy.
Explanation:
Mechanism of tetracyclines: they bind to the 16s rRNA of the 30S subunit of the ribosome and cause concentration-dependent effects on protein synthesis
