Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
the role of plants in carbon cycle
Explanation:
the amount of CO2 found in the atmosphere varies over the course of a year. much of this variation happens because of the role of plants in carbon cycle...respiration occurs all the time, but domains during the colder months of the year, resulting in higher CO2 levels in the atmosphere during those months.
The correct answer is: ensure that all tubes are attached to collection devices
An adequately functioning nasogastric (NG) tube should prevent nausea and vomiting because stomach contents are continuously being removed. Using the NG after abdominal surgery is a routine postoperative procedure until gastrointestinal tract starts to function properly. The patency of the tube should be checked together with the amount and character of gastric drainage.
Answer:
a. glycolysis—preparatory reaction--cirtric acid cycle--electron transport system
Explanation:
- Glycolysis is the first stage of cellular respiration that occurs in the cytoplasm of the cell. During glycolysis one 6 carbon glucose is converted into two molecules of 3 carbon pyruvic acid or pyruvate.
- In the preparatory reaction, the pyruvate converted into a two-carbon molecule called acetyl CoA. In this reaction, a carbon dioxide molecule is released and a molecule of NADH is released.
- The citric acid cycle begins with the reaction of the acetyl CoA with a four-carbon molecule in the mitochondrisl matrix. It goes through a cycle of reactions regenerating the four-carbon starting molecule. ATP, NADH and FADH₂ are produced.
- The electron transport system is the terminal step of aerobic respiration that operates on the inner membrane of the mitochondria. Reduced coenzymes NADH and FADH₂ move along electron transport system release high-energy electrons and produce ATP.
