Answer:
Are you asking what factors effect mutation rate?
If you are could you be a little more specific because technically even you just damaging tissue increases the likelihood of a mutation occurring due to mitosis occurring to repair the destroyed cells. So every time you have to replicate DNA you’re at risk an increased risk for mutation assuming it was the result of something like a cut.
sorry I have to go
It's the epidermis, because it is the outermost layer of our skin, it creates a waterproof barrier and creates skin color pigmentation.