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Chemically altered nucleosides derived from canonical ribo-or deoxyribonucleoside-derivatives of adenosine, cytosine, guanosine, and uridine or thymidine are found in all types of nucleic acids, DNA and RNA. They are particularly abundant in noncoding RNAs, such as transfer RNAs and ribosomal RNA of higher organisms. By increasing the structural diversity of nucleic acids, modified nucleosides play important roles in gene expression and in regulating many aspects of RNA functions. They also contribute to nucleic acid stability and to protection of genetic materials against virus aggression. In this chapter we present a historical overview of the discovery, occurrence, and diversity of the many naturally occurring modified nucleosides that are present in both DNA and RNA of diverse organisms. We also briefly describe the different enzymes that accomplish these nucleic acid ‘decorations’. More information about the structure, function, biosynthesis and evolutionary aspects of selected modified nucleosides in DNA and RNA and their corresponding modification enzymes can be found elsewhere in this volume.
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Whole grains
Fruits
Dairy
Fish, poultry, meat, eggs
Heart-healthy oils
Elective or Discretionary Calories.
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Learning how to control their eating
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Untreated, hereditary hemochromatosis can lead to a number of complications, especially in your joints and in organs where excess iron tends to be stored — your liver, pancreas and heart. Complications can include:
Liver problems. Cirrhosis — permanent scarring of the liver — is just one of the problems that may occur. Cirrhosis increases your risk of liver cancer and other life-threatening complications.
Pancreas problems. Damage to the pancreas can lead to diabetes.
Heart problems. Excess iron in your heart affects the heart's ability to circulate enough blood for your body's needs. This is called congestive heart failure. Hemochromatosis can also cause abnormal heart rhythms (arrhythmias).
Reproductive problems. Excess iron can lead to erectile dysfunction (impotence), and loss of sex drive in men and absence of the menstrual cycle in women.
Skin color changes. Deposits of iron in skin cells can make your skin appear bronze or gray in color.