John L. O'Sullivan made this quote in 1845. The idea motivated many Americans to be focused and have big dreams. Many of them migrated to the West with the hope of taking over the whole of the continent. They were confident that their country is destined to be a great nation. Human liberty, civilization and a stable political system were the ruling powers in the American economy. They have had patriots to defend their homes and liberties because of the democratic equality in their system of government. This nation of progress values equality of rights as a way of assuring happiness to its citizens.
No, grandparents is a common noun, therefore you don't capitalize it. It would be different if you had the names of the grandparents. Like if your grandma is named Martha. You would have to capitalize their name since it is a proper noun