Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
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A buffer is a solution encompassing a weak acid and its conjugate base in alike amounts. This combination reduces the pH change upon addition of strong acid or base by converting H1+ (or OH1-) to weaker acids or bases. This primarily consist of compounds that stabilize the pH of a solution by removing or replacing hydrogen ions. Also, substances that resist change in pH.
Given what we know about the biological mechanisms behind anaerobic exercise, we can confirm that the production of lactate ensures a continuous supply of NAD.
In order for us to undergo any physical exercise, it is imperative that we are able to produce energy within our cells. The energy used by cells is in the form of a molecule by the name of ATP, which is produced primarily through a process known as <em>Glycolysis</em>.
This is relevant given that in order for glycolysis to happen, a key protein is required known as NAD+. Lactate is produced from pyruvate only under anaerobic conditions because these are conditions that lack oxygen which is the only other source of NAD+, therefore, pyruvate must be converted to lactic acid to make it possible to continue glycolysis and the production of ATP.
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Answer:
The gametophyte is green and nutritionally independent in mosses, liverworts, and fern.
Explanation:
The gametophyte is the sexual stage of growth in plants and algae.
During this stage, there is production of reproductive organs which produce sex cells.
During this stage, the gametophyte is independent since it relies fully on itself for food production.
The presence of chlorophyll enables this independence.
The gametophyte produces its own food through photosynthesis.
Answer:
C. All fossils contain intact DNA that can be sequenced.
Explanation:
Fossils are the impression, trace or preserved remains of once-living thing from past thousands of years such as bones, exoskeletons, objects preserved in amber, and stone imprints of animals or microbes.
Fossils provide evidence about seevral characteristics and features of extinct organism such as evolutionary relationship between organisms and transitional forms between groups of organisms. but all the fossil do not provide evidence about the intact DNA that can be sequenced because some fossils carry DNA rumnants which do not have the ability to get sequenced.
Hence, the correct option is C.
