The Entner-Doudoroff pathway is one of the three glycolytic pathways that breakdown glucose into pyruvate. The Entner-Doudoroff pathway is the most common glycolytic pathway in microbes present in the soil such as <em>Rhizobium, Azotobacter,</em> etc.
The Entner-Doudoroff pathway forms glucose 6-phosphate from glucose which in turn is oxidized into 6-phosphogluconate. The 6-phosphogluconate finally forms pyruvate and glyceraldehyde 3-phosphate through a series of reactions. The glyceraldehyde 3-phosphate can enter the Embden-Meyerhof pathway to form one more molecule of pyruvate. During the Entner-Doudoroff pathway, one molecule of ATP and one NADPH are formed along with the formation of one molecule of each pyruvate and glyceraldehyde.
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