Question

Do any cells in the population express Glut4 on their surface? Is this expression dependent on the presence of insulin receptor? Is this expression dependent on the presence of insulin? Explain.

Answer 1

Answer:

Glut4 is only expressed in insulin-sensitive skeletal an heart muscles and fat tissues.  

Explanation:

Glucose transporters represent a group of integral membrane proteins that allow the transport of glucose molecules across the plasma membrane by the mechanism of facilitated diffusion (i.e., without direct coupling to ATP hydrolysis). In humans, the Glucose Transporter type 4 (GLUT-4) is a glucose transporter encoded by the SLC2A4 gene. This protein plays a critical role in regulating glucose homeostasis by enabling to increase the transport of glucose in response to elevated blood insulin levels in adipocytes, skeletal and cardiac muscle tissues.