<span>The difference in synthesis of lagging strand compared to synthesis of the leading strand is D) Synthesis of the leading strand does not involve RNA primers and Okazaki fragments. DNA polymerase adds nucleotides at the 3' end toward the 5' end in the direction 3' to 5'. The free end of the lagging strand is 5' so DNA polymerase cannot start from that end. The replication of the lagging strands is discontinuous and it involves RNA primers and Okazaki fragments. Synthesis of the leading strand is under control of DNA polymerase.</span>
As the DNA double helix is unwound by helicase, replication occurs separately on each template strand in antiparallel directions. This process is known as semi-conservative replication because two copies of the original DNA molecule are produced. Each copy contains one original strand and one newly-synthesized strand.
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