Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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"Static electricity is the result of an imbalance between negative and positive charges in an object. These charges can build up on the surface of an object until they find a way to be released or discharged. One way to discharge them is through a circuit. ... Remember, objects with the same charge repel each other." ~ www.loc.gov
Essentially saying that if you have a lot of friction, it will create a positive and negative electric charge, this electric charge also contains a small magnetic field which is static electricity.
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Answer:
The air is full of water, as water vapor, even if you can't see it. Condensation is the process of water vapor turning back into liquid water, with the best example being those big, fluffy clouds floating over your head. And when the water droplets in clouds combine, they become heavy enough to form raindrops to rain down onto your head.
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Answer:
Answer: 2
Explanation:
I do not not know a VOC resource is, but it is not the answer. The answer is B, a rapidly renewable resource.
Somethings are by products. Silver and Gold can be byproducts of copper, but Bamboo is a primary resource. You use it as soon as you grow it.
Answer 2
