1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Vilka [71]
4 years ago
11

How does thrombospondin-1 (Tsp-1) signaling selectively inhibit the proliferation of immature endothelial cells without affectin

g mature endothelial cells participating in the formation of blood capillaries?
Biology
1 answer:
lord [1]4 years ago
3 0

Answer:

ascular endothelial cells are an established source of thrombospondin 1 (TSP1), a multifunctional extracellular matrix molecule. TSP1 appears to play an important role in modulating endothelial cell functions such as proliferation, migration, and capillary morphogenesis. In addition, TSP1 has recently been reported to potently inhibit angiogenesis both in vitro and in vivo. To better understand the mechanism underlying the antiangiogenic property of TSP1, endogenous TSP1 production was disrupted in bovine aortic endothelial cells (BAEC) by stable transfection with a vector expressing a TSP1 antisense RNA. Stable transfectants in which the antisense vector caused a decrease in TSP1 production were assayed for their ability to form capillary-like cords on gelled basement membrane matrix and for their responsiveness to the angiogenic/chemotactic mediator basic fibroblast growth factor. BAEC in which TSP1 production was disrupted exhibited a ten-fold increase over control BAEC in chemotactic activity to basic fibroblast growth factor and a twofold increase over control cells in the number of capillary-like cords that formed on gelled basement membrane matrix. Thus, the down-regulation of endogenous TSP1 appears to facilitate endothelial cell chemotaxis and capillary morphogenesis. These studies suggest that the modulation of TSP1 production is an important component of the angiogenic response, and support the idea that soluble TSP1 inhibits angiogenesis by interfering with endothelial cell chemotaxis and capillary formation.

Explanation:

You might be interested in
Need help, asap please
Andrews [41]

Answer:

Please show the options

Explanation:

7 0
3 years ago
How is carbon dioxide produced in a cenent plant
Natali5045456 [20]
Carbon dioxide is emitted as a by-product of clinker production an intermediate product in cement manufacture, in which calcium carbonate (CaCO3) is calcinated and converted to lime (CaO), the primary component of cement. CO2 is also emitted during cement production by fossil fuel combustion.
6 0
3 years ago
Read 2 more answers
which of the following terms does not refer to the shape of a bacterium? a. tetanus b. bacillus c. spirillum d. coccus
dusya [7]
A. Tetanus does not refer to the shape of a bacterium.
4 0
3 years ago
Onsidering that gluconeogenesis requires a net input of 4 atp equivalents compared to glycolysis, why would a cell utilize this
Pani-rosa [81]

The process by which organisms create sugars (specifically glucose) from non-carbohydrate precursors is known as gluconeogenesis.

  • The only energy source used by the brain, testes, erythrocytes, and renal medulla is glucose, with the exception of ketone bodies during fasting. There are three highly exergonic stages in glycolysis. Hexokinase, phosphofructokinase, and pyruvate kinase are among the enzymes involved in these additional regulatory stages. In biological processes, both forward and backward reactions are possible.
  • Similar to glycolysis, but with the process going the other way, is gluconeogenesis. Fructose-1,6-bP, glucose-6-P, and pyruvate all undergo fairly spontaneous conversions in the process of gluconeogenesis, which is why these reactions are tightly controlled.
  • For the organism to function properly, energy conservation is crucial. Gluconeogenesis is suppressed when there is an abundance of energy available.

Therefore, gluconeogenesis conserve more energy.

Learn more about gluconeogenesis:

brainly.com/question/1425339

#SPJ4

6 0
1 year ago
40. How is the biodiversity of an ecosystem measured?
Slav-nsk [51]

Answer:

i hope this helps

Explanation:

3 0
4 years ago
Read 2 more answers
Other questions:
  • hen the graylag goose accidentally knocks an egg from her nest, she extends her neck and moves her beak and neck in a side-to-si
    12·1 answer
  • A doctor hypothesizes that a patient's digestive system is not properly secreting digestive enzymes. Which of the following woul
    11·2 answers
  • PLEASE HELP!
    14·1 answer
  • Homeostasis is the state of maintaining a stable what?
    10·1 answer
  • What is the mantle of the core of the earth
    8·2 answers
  • Why would DNA need to replicate ? Two reasons
    6·1 answer
  • Which of the following statements is true for a eukaryotic cell?
    5·1 answer
  • 1. A phenotype is an inherited feature that varies from individual to individual. 2. A is one particular variation of a characte
    8·1 answer
  • how the skin cells, neurons, muscle cells, and blood cells you have observed relate to the functions of skin, nerve, muscle, and
    13·1 answer
  • Most crabgrass preventers are applied is early spring.
    12·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!