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Nata [24]
3 years ago
10

When utilizing a KO mouse model, you want to see if introducing the dystrophin gene can rescue the DMD mouse model. Propose a me

chanism to (re)introduce dystrophin back into the KO mouse.
Biology
1 answer:
-BARSIC- [3]3 years ago
4 0
<h2>CRISPR/Cas9</h2>

Explanation:

CRISPR can be used to reintroduce dystrophin back into the KO mouse

  • CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats and is used to for gene editing
  • CRISPR/Cas-mediated genome editing has been shown to permanently correct DMD mutations and restore dystrophin function in mouse models
  • Germline editing by injecting zygotes with CRISPR/Cas9 editing component was first done in mdx mice by correcting the mutated exon 23
  • Postnatal editing of mdx mice was then achieved using recombinant adeno-associated virus to deliver CRISPR/Cas9 genome editing components and correct the dystrophin gene by skipping or deleting the mutated exon 23 in vivo
  • Germline and postnatal CRISPR/Cas9 editing approaches both successfully restored dystrophin function in the mice and same technique can be used for KO mouse model
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This question is incomplete

Explanation:

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