The exchange that most affected the indigenous people was the one of diseases. Native Americans hadn't encounter the diseases the European brought before, so they hadn't develop immunity to them. This is the major reason of the large death of Native Americans, besides the war between them and the brutality of the Europeans.
The Pullman strike was caused by the panic of 1893, George Pullman, which increased hours for working and they cut down wages.
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There was an atomic bomb and a number of people were injured and died
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