It's the same reasoning as why insurance gives better deals to people of greater age.. They are seen to have more experience and be more "mature " to drive safer if you have more years driving your insurance goes down.. same concept
If a proteins shape was changed it may be able to do its function to do being unable to fit in all blood vessels/arteries and the shape change may of hindered its capability of carrying nutrients it needs to transport, etc.
for example:
If a hemoglobin (red blood cell) shape changed, (this is normally called sickle cell) the red blood cell would be to unable to travel through the body with ease and easily clog bloodstreams. Also, the hemoglobin will not be able to transport as much oxygen throughout the body.
Input: information you put into a system
throughput: information that is going through the system
output: information that comes out of the system
