Question

Endogenous antigens processed in proteasomes are delivered by ____________ into the endoplasmic reticulum where they can then associate with ____________ for eventual transport to the plasma membrane and presentation to CD8 T cells.

Answer 1

Answer:

1. Transporter associated with antigen processing (TAP)

2. MHC class I

Explanation:

Antigens will be cut by proteasome into smaller cuts of peptides that can be caught by TAP. Transporter associated with antigen processing or TAP located in ER lumen will help to deliver it to major histocompatibility complex  (MHC) class I.  When MHC class I identify it as a foreign antigen, some of the antigens will be sent to the plasma membrane. This allows cytotoxic T cell(CD8) to be able to detect the antigen on the cell membrane and proceed to kill the infected cell.