1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
balu736 [363]
3 years ago
12

Amyloidosis is caused by an abnormal deposition and accumulation of protein aggregates in tissues. How do proteins adopt and mai

ntain a stable folded structure? What features of the protein amino acid sequence determine the stability of the folded structure? How does disruption of that structure lead to protein deposition diseases such as amyloidosis, Alzheimer's disease, and Parkinson's disease?
Biology
1 answer:
Aleksandr [31]3 years ago
3 0

Answer:

How do proteins adopt and maintain a stable folded structure? What features of the protein amino acid sequence determine the stability of the folded structure?

Proteins are formed by three-dimensional structures (twisted, folded or rolled over themselves) determined by the sequence of amino acids which are linked by peptide bonds. Among these bonds, what determines the most stable conformation of proteins is their tendency to maintain a native conformation, which are stabilized by chemical interactions such as: disulfide bonds, H bonds, ionic bonds and hydrophobic interactions.

How does disruption of that structure lead to protein deposition diseases such as amyloidosis, Alzheimer's disease, and Parkinson's disease?

The accumulation of poorly folded proteins can cause amyloid diseases, a group of several common diseases, including Alzheimer's disease and Parkinson's disease. As the human being ages, the balance of protein synthesis, folding and degradation is disturbed, which causes the accumulation of poorly folded proteins in aggregates, which can manifest itself in the nervous system and in peripheral tissues. The genes and protein products involved in these diseases are called amyloidogenic and all of these diseases have in common the expression of a protein outside its normal context. In all these diseases, protein aggregation can be caused by mere chance, by protein hyperphosphorylation, by mutations that make the protein unstable, or by an unregulated or pathological increase in the concentration of some of these proteins between cells. These imbalances in concentration can be caused by mutations of the amyloidogenic genes, changes in the amino acid sequence of the protein or by deficiencies in the proteasome.

Explanation:

You might be interested in
Assessing biodiversity:
Helen [10]

Answer:

The correct answer will be option-A

Explanation:

Biodiversity refers to the diversity of the biological entities present in an ecosystem. Biodiversity has a wide spectrum which not only includes the number of the diversity of the organism but also the interaction between them.

The biodiversity is assessed to study the changes that are taking place in an ecosystem, to study the causes and how the changes affect the human well being.

The assessment decisions ignore the personal interests and the biasness as the aim of the approach is not fulfil the personal needs but to maintain sustainable management of the ecosystem.

Thus, option-A is the correct answer.

8 0
3 years ago
Which of these cells is likely to NOT continue to divide?
OleMash [197]
Nerve cells because skin cells keep dividing when you loose skin. Epithelial cells also divide when you loose others.
3 0
3 years ago
A ______ is a regulatory molecule that is secreted into the blood by an endocrine gland.
Oksana_A [137]
A hormone is a regulatory molecule that is secreted into the blood by an endocrine gland
5 0
3 years ago
The ability of vibrio cholerae to cause disease depends on a number of factors. What are general requirements for any organism t
Svetllana [295]
<h2>Disease </h2>

Explanation:

  • Pathogenicity is the ability to produce disease in a host organism
  • Microbes express their pathogenicity by means of their virulence, a term which refers to the degree of pathogenicity of the microbe
  • The relationship between a host and a pathogen is dynamic, since each modifies the activities and functions of the other
  • The outcome of such a relationship depends on the virulence of the pathogen and the relative degree of resistance or susceptibility of the host, due mainly to the effectiveness of the host defense mechanisms
  • Hence, general requirements for any organism to cause disease within a host are: evasion of host defenses , gaining access to the host via a portal of entry, adherence to host tissues

 

4 0
3 years ago
4.<br> Which is not a major mineral group?
ddd [48]
The correct answer should be: Bromide
4 0
3 years ago
Other questions:
  • Microscopic, single-celled organisms that have a complex structure similar to animals and plants are known as
    8·1 answer
  • Some plants and animals can reproduce both asexually and sexually. true false
    10·2 answers
  • New genetic strains of crops have been developed, yielding significantly higher amounts. the use of high-yield hybrid crops is c
    11·2 answers
  • Why does using two different enzymes to cut the plasmid prevent the plasmid from reforming a circle without the inserted gene?
    6·1 answer
  • Recognize<br> 4. What landforms are<br> common in a coastal<br> depositional environment?
    15·1 answer
  • Which of the following codons code for threonine?
    11·1 answer
  • How do crosscutting concepts help unite the study of biology?
    8·2 answers
  • Which of the following molecules do you think would make good antigens for recognizing an extracellular pathogen? Write a brief
    14·1 answer
  • THE RIGHT ANSWER WILL RECIEVE A BRAINLEST AND POINTS AND THANXS!!!
    13·2 answers
  • Ocean dumping is a source of pollution for _____.
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!