Answer:
E. Interleukin-1
Explanation:
Interleukin-1 is produced by macrophages and is involved in promoting the proliferation of helper T cells. Interleukin-1 also acts on the hypothalamus to cause fever. Fever refers to abnormally high body temperature. During infection and inflammation, the hypothalamic thermostat is reset in response to interleukin-1 resulting in fever. The presence of certain bacterial toxins in the body triggers the release of interleukin-1 from macrophages and the body temperature is elevated. Fever inhibits the growth of some microbes, intensifies the effects of interferons, and stimulates the body's immune reactions.
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