Paliperidone has low affinity
for lipid-rich environments compared from the parent compound risperidone. Due to
its hydrophilicity characteristic, paliperidone is capable of hydrogen bonding
with other molecules containing water and hydroxyl groups. Lipophilicity is a
determining factor for the rate and degree of metabolism of the drug in the
body and for crossing the blood–brain barrier (BBB).
Moreover, these differences are
implicated in synaptic plasticity and neuronal firing effects in the mechanism
of mitochondrial movement, protein expression, and phosphorylation of the drug.
Paliperidone as a mood stabilizer is an active metabolite of risperidone with antipsychotic effects used
for the treatment of schizophrenia and its associated disorders.
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I think it’s the digestion
The smallest unit is species
