<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
The answer to this question is a
This condition is known as a super oxide in which mutated enzyme extremely functional because it helps in production of cells .
when unstable molecules that contains oxygen and that easily react with other molecules in the cells. a build up of reactive oxygen species and cells causes damage of DNA ,RNA & protein ,which cause cell death.
super oxide refers various toxic oxygen containing free radicals such as monovalant anion O2 (negative) or that compound containing potassium super oxide KO2. reactive oxygen can cause damage to the basic building block of the cell. DNA damage can occur in the form of double stranded breaks as a result of reactive oxygen induced conversion of guanine to 8-oxo guanine.
To learn more about the cell death here
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It's called appendages if that is what you need
