Answer:
Catastrophe
Explanation:
Analogies are fun. In this one, difference is to opposite as catastrophe is to disaster. Difference and opposite are synonyms, so the blank is a synonym.
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I think the word with should be replace with the word for.
“The cough is a mere nothing. It will not kill me. I shall not die of a cough” this part of the passage is very ironic because he really won’t die of a cough but he is explaining the cough to be nothing for him to be worried about
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