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Answer:
Hi!
The answer is (C) Both (a) and (b)
Explanation:
Drug Metabolism:
- Drug metabolism is divided into two steps: Phase 1 and Phase 2 reactions.
- Phase 1 reactions involve the degradation or formation of functional groups.
- Phase 2 reactions involve the conjugation of the drug or its Phase 1 intermediate with a polar conjugating molecule. Phase 2 generally performs the detoxification step in the drug degradation process.
- Phase 2 or conjugation reactions are further divided into 2 types:
- Type 1: Glucoronidation and sulfonation: An activated conjugating molecule such as glucoronic acid, sulfate or glutathione etc. is combined with the drug to form a conjugated molecule.
- Type 2: Amino acid conjugation: An activated drug or substrate is conjugated with an amino acid such as glycine or glutamine.
Glutathione Conjugation:
Glutathione is a tripeptide found in most tissues, particularly in the liver. It performs important detoxification functions for all cells. The enzyme, glutathione S-transferase conjugates glutathione with drug intermediates to form a drug-glutathione conjugate. This conjugate can easily be excreted through bile or urine.
Amino acid Conjugation:
This is an important reaction in xenobiotic biotransformation; particularly for xenobiotics with carboxylic group or an aromatic hydroxylamine groups. Drug intermediates combine with glycine or glutamine to form an amino acid conjugate.
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