Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
I think it's B. The Start menu.
Answer:
A. Switches identify the intended destination of the data that they receive. And C. Switches are capable of sending and receiving data at the same time
Explanation:
Switches can be used as inputs (Analog), or outputs (digital). These inputs and outputs are signals that the switches send or receive- Or at least as push button switches... But the same applies to network switches.
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The major physiographic features are a massive highland complex of mountains and plateaus divided by the Great Rift Valley and surrounded by lowlands along the periphery. The diversity of the terrain is fundamental to regional variations in climate, natural vegetation, soil composition, and settlement patterns.