The answer is spicules. These
sharp-pointed structures are formed from calcium carbonate skeleton of
the organisms. They can also be formed from silica. They can be big (megascleres),
or microscopic (microscleres). Also dependent on the number of axis on the spicules, they are classified as monoaxon,
triaxon or polyaxon.
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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<span>The 4 categories of macromolecules include carbohydrates, proteins, lipids, and nucleic acids. Carbohydrates (grains and vegetables) are the largest group at the base of the pyramid, proteins (milk, poultry, eggs, nuts) follow up the pyramid while lipids (fats and oils) are the least amount at the summit of the pyramid. </span>
<span>
</span><span>The aim of the pyramid is to recommend ideal rations for a healthy diet. Carbohydrates provide most of the energy needs for the days’ activities hence taking the largest portion. Proteins are used in building muscles, f0r nutrition, and body’s immunity hence required in lesser amounts compared to carbohydrates. Lipids help the body store energy since they have thrice as much energy as carbohydrates.They also a constituent of cell membranes and also help deliver vitamins. They are required in the least amount to avoid obesity and related illnesses such as cardiovascular <span>diseases</span></span>
D)independent
Explanation:
An independent variable is a variable that is changed to test the prediction in an experiment. Independent variables are the cause in an experiment. They are the ones that produces the effect.
- Changing independent variables produces different effects in an experiment.
- These effects are the dependent variables
- Independent variables do not depend on the outcome of the experiment.
- They are the ones that determines how a reaction proceed and what might likely happen.
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