There was a lot of devestation and loss among people, from loss of loved ones to destroyed buildings.
Answer:
It increased the fighting between settlers and Indians, leading the settlers to claim more native American lands
Explanation:
Columbus and the other European explorers landing in the "new" world caused a massive outbreak of disease due to the lack of acquired immunity held by the native populations in North America.
This biological genocide wiped out a significant amount of the population in the New World making the future conquering of the people relatively easy for the Europeans.