Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Taxonomy is the science of naming and classifying organisms based on structural comparisons and genetic evidence.
Answer: The correct answer is black because the product of its side and mass is lower.
Explanation: Density of a substance is defined as the mount of matter that can be stored in a given volume.
Mathematically,
As, density is inversely proportional to the volume of the substance.
The substance will be more denser if it has less volume and it will be less denser if the volume is more.
We are given two cubes having different sides.
Volume of the cube is calculated by using the formula:
where, a = side of the cube.
Black: The side of this cube is 2 and volume will be = 
Yellow: The side of this cube is 3 and volume will be = 
As, the volume of black cube is less. So, this cube will be more denser.
Density of black cube: 
Density of Yellow Cube: 
Hence, black cube will be more denser because the product of its side and mass is lower.
