Coprophagy is important for the nutritional balance of rabbits and their relatives.
The behaviors of the rabbit, rat, mouse, hamster, guinea pig and chinchilla have all been linked to coprophagy, which is the act of an animal re-consuming its own discharged excrement. Cecotrophy is a better name for it.
The omnivorous rats, mice, and hamster display cecotrophy to a lesser level than herbivores' hindgut fermenters like the rabbit, guinea pig, and chinchilla. In order to boost the supply of folic acid and vitamin B12, it may rise during pregnancy and lactation.
Coprophagy is an intrinsic behavior triggered by the reflex, despite the fact that modern diets make it unnecessary for survival.
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Their location, or layer
The cells produce three germ layers:
endoderm- becomes the gut
mesoderm- becomes muscle, skeletal system, some organs, and connective tissure
ectoderm- becomes skin and nervous system
<span>Segregation would be the answer :)</span>
Answer:
a,the ability to go from a single cell to multicellular organism
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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