These medicines are called antisecretory because they work by blocking the acid secretion of the stomach.
This is the case of the H2 antihistamine (such as Cimetidine) which has a rapid action (approximately 1 hour) but longer than an antacid.
When symptoms are frequent, occurring more than once a week, proton pump inhibitors (PPIs) (such as Omeprazole), antisecretory agents of potent and prolonged action (at least 24 hours), constitute the treatment of choice.
A medication that increases the pH of the stomach and makes it alkaline is actually helping in neutralizing the acid forming in the stomach.
When there is excess of acid into the stomach then intake of a base helps in balancing the excess of acid by providing suitable amount of hydroxide ions.
Thus, we can conclude that this medication will have a neutralizing effect.
