Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:
- The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
- Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
- Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
- Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
- Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
- Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
- The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.
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Answer:
chloroplast is the organelle
Answer:
A) polar
Explanation:
Polar molecules contains partial positive and partial negative charge as in all polar molecules two atoms have unequal sharing electron. Due to unequal sharing of electrons, one atom that attracts valence electrons strongly gains positive charge and other gain negative charge.
For example water, water is a polar molecule having partial negative and partial positive charge because the oxygen atom in water attracts electrons more strongly than the hydrogen atoms.
Hence, the correct answer is "A) polar".
False. Interphase is not technically a part of mitosis.
During interphase, the cell is performing its normal functions and preparing for mitosis.
Answer:
sorry if my answer is incoplete.
