Question

Progeria is a genetic disorder that causes numerous symptoms that resemble premature aging in patients. Progeria is caused by a dominant allele, and it always results in fatality before sexual maturity. Which statement must be true about progeria?a. Both parents of every progeria patient must also be carriers of progeria. b. Progeria must be more common in some geographic areas than in others. c. Every case of progeria must be caused by a new mutation. d. At least one parent of every progeria patient must also be a carrier of progeria. e. Progeria must be relatively common.

Answer 1

Answer:

C. Every case of progeria must be caused by a new mutation.

Explanation:

Progeria is a rare disease which is caused by the defect in the production of the progerin protein or the lamin A.

The progeria is caused when a mutation on the gene which codes for the lamin A protein occurs. The progerin protein is involved in forming the nuclear lamina and thus maintain the structure of the nucleus. When the nucleus lacks the protein then the nucleus becomes unstable and the cell dies at an early age.

Since the condition is caused by the dominant allele and the baby dies before the sexual stage, therefore, the allele is not transferred and there are no chances that the disease is an inherited disease but by a new mutation in a gene.

Thus, Option-C is correct.