Option C. Columbus underwent deep voyages and discovered the present day America. He also discovered the marine route which associated the old Eastern world to the new Western world.
After the establishment of Sea route there was exchange of goods with other countries started. But the negative impact was that people of Eurasia were not healthy with high levels of immunity.
The interchange of food supplies also initiated the arrival of dangerous diseases too and major part of the European, native American and Asian population died causing shortage of human labor, this gradually lead to the slavery of Africans.
The US foreign policy distanced it from Cuba, in not only diplomatic relations , but trade, etc.
Originally, Ancient Rome practiced politheism, however poor people and slaves gradually started to believe in Christianity as a way of salvation to they miserable lives. The expansion of Christianity could not be stopped by the Emperors, which resulted in Emperor Constantine made it legal in 313 AD and eventually, the workship of other gods was made illegal in 391 AD.
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These are the challenges that is facing east asia region development contribute to many environmental problems in Asia. These include pressure on land, habitat destruction and loss of biodiversity, water scarcity and water pollution, air pollution, and global warming and climate change.
