An enzyme is a protein that speeds up a chemical reaction. Enzymes are <u>shape specific</u>. The active site is a specific shape, which means it can only break down specific substrates.
Certain conditions can <u>denature</u> enzymes. For example, extreme temperatures or pH will cause the enzyme to deform and change shape, which means it cannot perform its job.
Therefore, the best choice is the second one: <em>enzymes work best in specific conditions and only break down specific substrates.</em>