The first African slaves were brought to the Jamestown Colony in what is today Virginia. Jamestown was settled in 1607 and it wasn't long before the colony moved past the used of indentured workers to slaves without a contract. By the 1620s, the Jamestown colony was actively bringing in slaves for farms.
One of the immediate results of the fall of the Roman Empire in the West was that the area soon became home to a great deal of lawlessness, since the Roman armies were no longer there to safeguard.