Adenylate cyclases (ACs) are the membrane-bound glycoproteins that convert ATP to cAMP and pyrophosphate.
When activated by G-protein Gs, adenylate cyclases (ACs), which are membrane-bound glycoproteins, catalyze the synthesis of cAMP from ATP.
Different AC isoforms are widely expressed in various tissues that participate in regulatory systems in response to particular stimuli.
Humans have 9 different AC isoforms, with AC5 and AC6 thought to be particularly important for cardiac activities.
Nitric oxide has an impact on the activity of AC6, hence the protein's nitrosylation may control how it works. However, little is known about the structural variables that affect nitrosylation in ACs and how they relate to G's.
We predict the cysteines that are prone to nitrosylation using this 3D model, and we use virtual ligand screening to find potential new AC6 ligands.
According to our model, the AC-Gs interface's Cys174 in G's and Cys1004 in AC6 (subunit C2) are two potential residues that could experience reversible nitrosylation.
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Answer:
C. high construction costs
Explanation:
Answer:
a. Uninucleate, nonstriated
Explanation:
Smooth muscle tissue is composed of smooth muscle cells that are spindle-shaped with a single nucleus. Smooth muscles line the walls of hollow organs such as urinary bladder, uterus, stomach, intestines but also arteries and veins and the tracts of the respiratory, and reproductive systems. Smooth muscles are under involuntary control, meaning that their contraction is unconscious.
Answer:
B
Explanation:
Mitosis is used to grow (makes diploid)
Meiosis is used to make haploid gametes
Answer:
sigma subunit
Explanation:
Sigma subunit of RNA polymerase holoenzyme directs the enzyme towards the consensus sequences present upstream of the transcription start site. Completion of the initiation phase of transcription is followed by dissociation of sigma subunit from the transcription complex.
The protein NusA replaces the sigma subunit. The RNA polymerase leaves the promoter and starts the elongation
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